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Polyvinylpyrrolidone, cross-linked(PVPP) (939501)
Details:

Synonym: Poly(vinylpolypyrrolidone)    
      
CAS NO.:25249-54-1; 9003-39-8

Molecular Structure:

                     Crospovidone

Properties:
White or cream white,free-flowing powder,hygroscopic,odourless or with characteristic smell,insoluble in water,alkali,acid and all other common solvents,swells rapidly in water but without forming a gel.

Quality Standard:Ph.EP,USP/NF

  Product      

PolyKoVidoneTM -XL

(Type A)

PolyKoVidoneTM -10

(Type B)

Appearance

White or yellowish-white powder or flakes

Water-soluble substances     % max.

1.0

1.0

pH Value (1% in water)

5.0-8.0

5.0-8.0

Loss on Drying      % max

5.0

5.0

Sulphate ash  % max

0.1

0.1

Nitrogen Cotent     %

11.0-12.8

11.0-12.8

Impurity A(Vinylpyrrolidone)  ppm max

10

10

Peroxide(As H2O2)         ppm max

400

1000

Heavy metals      ppm max

10

10

Partical size (µm),  ≥80%

50-250

5-50

Applications:
To assure the effectiveness of the medicine,tablets and capsules are required to disintegrate within a certain time,if different adding methods of the disintegrating agent are used,the different disintegrating and dissolution speeds witll be achieved.PolyKoVidone is regarded as the top disintegrating agent thanks to its excellent swelling characteristics after the absoption of moisture.

  • Highly efficient disintegrating agent:Makes all excipients swell quickly,effective for wet & dry granulations and direct compression formulations,PolyKoVidone can be added before or after granulation.Its swelling action and disintegration time will be not impacted by wetting or drying.
  • Suspension stabilizer: PolyKoVidone acts as a hydrophilic polymer,increasing the viscosity,improving the dispersal capacity,reducing the sedimentation rate of drugs,meanwhile,increasing the redispersal capacity of the solution sediment,suitable for liquid preparations and instant oral preparations.
  • Complextant of drug ingredients:Stablizing the active ingredients in pharmaceutical products,improving the dissolution and bioavailability.
  • Complextant of Tannin and Polyphenols:In the aqueous or alcoholic herbal extracts,Polyphenols are absorbed selectively by PolyKoVidone and complexed,and finally filtered off.
  • Moisture Absorbent.

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